Acromegaly primarily results from an excess of which hormone?

Acromegaly is a hormonal disorder that arises from the overproduction of growth hormone, usually due to a benign tumor on the pituitary gland. The excess growth hormone leads to the enlargement of bones and soft tissues, causing noticeable changes in physical appearance such as enlarged hands, feet, and facial features. The condition can also lead to various metabolic complications and increased risk of other health issues, such as diabetes and cardiovascular disease.

While other hormones like thyroid hormone, cortisol, and insulin play significant roles in metabolism and bodily functions, they are not directly responsible for the symptoms and pathophysiology associated with acromegaly. The distinctive features of this disorder are uniquely tied to the effects of growth hormone, making it the correct choice in identifying the primary hormone involved in acromegaly.